Coxsackievirus and Adenovirus Receptor in Endometrial Cancer
Author Information
Author(s): Giaginis Costas T, Zarros Apostolos C, Papaefthymiou Maria A, Papadopouli Aikaterini E, Sfiniadakis Ioannis K, Theocharis Stamatios E
Primary Institution: Department of Forensic Medicine and Toxicology, Medical School, University of Athens, Greece
Hypothesis
What is the clinical significance of CAR expression in endometrial adenocarcinoma?
Conclusion
The study found that CAR expression is associated with important clinicopathological parameters in endometrial adenocarcinoma, although it did not predict patient survival.
Supporting Evidence
- CAR positivity was noted in 56% of the examined endometrial adenocarcinoma cases.
- High CAR expression was noted in 35% of the positive cases.
- CAR positivity was significantly associated with tumor histological grade.
- CAR staining intensity was significantly associated with tumor histological type.
Takeaway
This study looked at a protein called CAR in cancer samples from women with endometrial cancer to see if it could help doctors understand the disease better.
Methodology
Immunohistochemical assessment of CAR expression in tumor samples from 41 patients with endometrial adenocarcinoma.
Limitations
The study did not find significant associations between CAR expression and patient survival.
Participant Demographics
Mean age of participants was 63.4 years, with a range from 40 to 82 years.
Statistical Information
P-Value
p = 0.036 for histological grade association
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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