VEGF-C and Pelvic Lymph Node Status in Cervical Cancer
Author Information
Author(s): Hashimoto I, Kodama J, Seki N, Hongo A, Yoshinouchi M, Okuda H, Kudo T
Primary Institution: Okayama University Medical School
Hypothesis
The study investigates the relationship between VEGF-C mRNA expression and pelvic lymph node status in invasive cervical cancer.
Conclusion
Higher VEGF-C mRNA expression is associated with pelvic lymph node metastasis and poorer prognoses in cervical cancer patients.
Supporting Evidence
- VEGF-C mRNA expression was markedly higher in tumours with pelvic lymph node metastasis.
- Higher VEGF-C expression was found in tumours with deep stromal invasion.
- VEGF-C mRNA expression was the sole independent factor influencing pelvic lymph node metastasis.
- Patients with VEGF-C mRNA expression had significantly poorer prognoses.
Takeaway
This study found that a substance called VEGF-C in cervical cancer tissues can help predict if the cancer has spread to lymph nodes.
Methodology
VEGF-C mRNA expression was assessed using reverse transcription-polymerase chain reaction.
Participant Demographics
75 patients with invasive cervical cancer, including 53 patients with stage Ib–IIb who underwent surgery.
Statistical Information
P-Value
P = 0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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