Risk of Oesophageal and Gastric Cardia Cancer in Asthma Patients
Author Information
Author(s): Ye W, Chow W-H, Lagergren J, Boffetta P, Boman G, Adami H-O, Nyrén O
Primary Institution: Karolinska Institute
Hypothesis
Does hospitalization for asthma increase the risk of adenocarcinomas of the oesophagus and gastric cardia?
Conclusion
Asthma is associated with a moderately elevated risk of developing oesophageal or gastric cardia adenocarcinoma, particularly in patients with gastro-oesophageal reflux.
Supporting Evidence
- Asthmatic patients had a moderately elevated risk for oesophageal adenocarcinoma (SIR = 1.5).
- Asthmatic patients had a moderately elevated risk for gastric cardia cancer (SIR = 1.4).
- The excess risks were largely confined to asthmatic patients with gastro-oesophageal reflux.
Takeaway
People with asthma might have a slightly higher chance of getting certain types of cancer in their throat and stomach, especially if they also have acid reflux.
Methodology
Cohort study following asthma patients hospitalized in Sweden from 1965 to 1994, using standardized incidence ratios to estimate cancer risk.
Potential Biases
Potential bias due to reliance on hospital records for asthma diagnosis.
Limitations
The study is limited to patients hospitalized for asthma and may not represent all asthma patients.
Participant Demographics
42,663 men and 50,323 women, hospitalized for asthma.
Statistical Information
Confidence Interval
95% CI, 0.9–2.5 for oesophageal adenocarcinoma; 95% CI, 1.0–1.9 for gastric cardia cancer.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website