Transcription and cancer
1991
Transcription and Cancer
publication
Evidence: moderate
Author Information
Author(s): P.M. Cox, C.R. Goding
Primary Institution: Transcriptional Control Laboratory, Marie Curie Cancer Research
Hypothesis
The review explores how perturbations in transcriptional control contribute to cancer development.
Conclusion
Deregulation of transcription can lead to inappropriate gene expression, contributing to cancer.
Supporting Evidence
- Deregulation of transcription can result in failure to express genes responsible for cellular differentiation.
- Current research is elucidating which elements of transcriptional control are important in neoplasia.
- Transcription factors regulating genes involved in cell growth and division may be inappropriately expressed in cancer.
Takeaway
Genes in our cells need to be turned on and off at the right times to keep us healthy, and when this goes wrong, it can lead to cancer.
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