Effects of Ulinastatin and Docetaxel on Breast Cancer Invasion
Author Information
Author(s): Luo Jie, Sun Xin, Gao Feng, Zhao Xiaoliang, Zhong Biao, Wang Hong, Sun Zhijun
Primary Institution: Second Affiliated Hospital of Chongqing Medical University
Hypothesis
This study investigates the effects of ulinastatin and docetaxel on the invasion of breast cancer cells and the expression of uPA, uPAR, and ERK.
Conclusion
Ulinastatin enhances the effects of docetaxel on the invasion of breast cancer cells and inhibits the expression of uPA, uPAR, and p-ERK.
Supporting Evidence
- Ulinastatin treatment significantly inhibited MDA-MB-231 and MCF-7 cell invasion.
- Ulinastatin decreased the mRNA and protein levels of uPA, uPAR, and ERK.
- Docetaxel treatment increased uPA, uPAR, and p-ERK levels.
Takeaway
This study found that a medicine called ulinastatin can help another medicine, docetaxel, work better against breast cancer by stopping cancer cells from spreading.
Methodology
Nude mice were treated with PBS, ulinastatin, docetaxel, and ulinastatin plus docetaxel, and their effects on cell invasion and protein expression were measured using various assays.
Participant Demographics
100 female BALB/c mice aged 4-6 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website