Serum B12, Folic Acid, and Homocysteine Levels in Thromboembolic Diseases
Author Information
Author(s): Bayır A, Karabulut K, Uçar A
Primary Institution: Selçuk University, Selçuklu Faculty of Medicine, Emergency Department, Konya, Turkey
Hypothesis
The study aims to compare the levels of serum B12, folic acid, and homocysteine in patients with thromboembolic diseases to those in a control group.
Conclusion
Patients with thromboembolic diseases had significantly higher levels of homocysteine and lower levels of vitamin B12 compared to healthy controls.
Supporting Evidence
- Mean serum homocysteine levels were significantly higher in the patient group than the control group.
- Plasma vitamin B12 levels were significantly higher in the patient group than the control group.
- Mean serum B12 values of the AMI and ICD groups were significantly lower than those of the control group.
- Serum folic acid values of the PAE and AMI groups were considerably lower than the control group.
Takeaway
The study found that people with certain blood clots have higher levels of a substance called homocysteine and lower levels of vitamin B12 compared to healthy people.
Methodology
The study included 100 patients with various thromboembolic diseases and 110 healthy controls, measuring their serum levels of B12, folic acid, and homocysteine.
Participant Demographics
100 patients with thromboembolic diseases and 110 healthy volunteers.
Statistical Information
P-Value
P = 0.002 and 0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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