Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells
2008
Prostaglandin E2 and Fas Ligand in Colon Cancer Cells
Sample size: 27
publication
Evidence: high
Author Information
Author(s): O'Callaghan G, Kelly J, Shanahan F, Houston A
Primary Institution: University College Cork, National University of Ireland
Hypothesis
The COX signalling pathway may play a role in FasL expression in colon tumours.
Conclusion
Prostaglandin E2 positively regulates FasL expression in colon tumour cells, contributing to immune evasion.
Supporting Evidence
- PGE2 increased FasL expression at both the mRNA and protein level.
- Suppression of COX-1 and COX-2 reduced FasL expression.
- A strong positive correlation was found between COX-2 and FasL expression in human colon cancer tissues.
Takeaway
This study found that a substance called prostaglandin E2 helps cancer cells in the colon make a protein that can protect them from the immune system.
Methodology
The study used RNA interference and immunohistochemical analysis to assess FasL expression in colon cancer cells.
Participant Demographics
Human colon adenocarcinoma tissues from 27 patients were analyzed.
Statistical Information
P-Value
<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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