Potential Biomarkers for Predicting Cancer Metastasis
Author Information
Author(s): Songjang Worawat, Nensat Chatchai, Jitpewngarm Wittawat, Jiraviriyakul Arunya
Primary Institution: Naresuan University, Thailand
Hypothesis
Can certain DAMPs serve as predictive biomarkers for the metastatic stage in various cancer types?
Conclusion
HSP90, HMGB1, and S100A9 show potential as predictive biomarkers for cancer metastasis.
Supporting Evidence
- HSP90 showed a cutoff value of 25.46 ng/mL with 82.61% sensitivity and 75.00% specificity.
- HMGB1 and S100A9 also demonstrated significant sensitivity and specificity as predictive biomarkers.
- Elevated levels of DAMPs were found in M1 patients compared to M0 patients.
Takeaway
Doctors can use certain proteins in the blood to help tell if cancer has spread to other parts of the body.
Methodology
The study measured serum levels of HMGB1, HSP90, S100A9, and ATP in cancer patients using immunological assays and analyzed correlations with cytokines.
Limitations
The study had a small sample size and included various cancer types, which may affect the baseline concentration of DAMPs.
Participant Demographics
55% male and 45% female, ages 42 to 86, with various cancer types including cholangiocarcinoma and colorectal cancer.
Statistical Information
P-Value
0.0013
Confidence Interval
95% CI 0.6860–0.9553
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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