Effects of Probiotics on Olanzapine-Induced Metabolic Syndrome
Author Information
Author(s): Mushraf Syed, Chawla Kiran, Fayaz Shaik Mohammed, Mathew Aranjani Jesil, Reddy Gayam Prasanna Kumar, Kappettu Gadahad Mohandas Rao, Shenoy Padmaja A., Devi Vasudha, Adiga Shalini, Nayak Veena
Primary Institution: Manipal Academy of Higher Education, Manipal
Hypothesis
Can probiotics mitigate the metabolic syndrome induced by olanzapine through modulation of gut microbiota?
Conclusion
Probiotics can counteract the adverse metabolic effects of olanzapine by restoring gut microbiota balance.
Supporting Evidence
- OLZ treatment caused significant weight gain in rats compared to the normal control group.
- Probiotic treatment mitigated OLZ-induced weight gain, hyperlipidemia, and hypertension.
- Probiotics increased serum serotonin and dopamine levels compared to OLZ treatment alone.
- Histopathological evaluation showed that probiotics maintained normal intestinal and liver architecture.
- Probiotics altered gut microbiota composition, increasing beneficial bacteria and decreasing harmful ones.
Takeaway
This study shows that giving probiotics to rats can help them stay healthy even when they take a medicine that usually makes them gain weight and feel bad.
Methodology
The study used a rat model to assess the effects of olanzapine and probiotics on metabolic syndrome parameters over 90 days.
Limitations
The specific probiotic strain responsible for the observed effects could not be identified due to the combination used.
Participant Demographics
Wistar albino rats, 2-3 months old, male.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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