Pin1's Role in Her2-Positive Breast Cancer
Author Information
Author(s): Lam Prudence B, Burga Laura N, Wu Bryan P, Hofstatter Erin W, Lu Kun Ping, Wulf Gerburg M
Primary Institution: Beth Israel Deaconess Medical Center, Harvard Medical School
Hypothesis
Inhibition of Pin1 might block the growth of Her2-positive breast cancer cells.
Conclusion
Pin1 is a novel regulator of erbB2 that modulates its degradation, and inhibiting Pin1 can suppress the growth of Her2-positive breast cancer cells.
Supporting Evidence
- Pin1 was found to be overexpressed in 62% of Her2-positive breast cancer specimens.
- Inhibition of Pin1 led to significant suppression of Her2-positive tumor cell growth.
- Pin1 inhibition increased the sensitivity of Her2-positive breast cancer cells to the mTOR inhibitor Rapamycin.
Takeaway
Pin1 is a protein that helps keep another protein called erbB2 stable in breast cancer cells. If we stop Pin1, it can help slow down the growth of these cancer cells.
Methodology
Immunohistochemistry for Her2 and Pin1 was performed on 223 human breast cancer specimens, and Pin1 inhibition was achieved using siRNA in Her2+ breast cancer cell lines.
Limitations
The study primarily focuses on in vitro results and may not fully represent in vivo conditions.
Participant Demographics
59% of specimens from primary cancers and 41% from metastatic sites.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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