Leukocyte Esterase Activity in Vaginal Fluid of Women
Author Information
Author(s): Per-Anders Mardh, Natalia Novikova, Ola Niklasson, Zoltan Bekassy, Lennart Skude
Primary Institution: Department of Obstetrics and Gynecology, University Hospital, Lund
Hypothesis
To determine the leukocyte esterase (LE) activity in vaginal lavage fluid of women with various conditions and compare results across different groups.
Conclusion
The use of commercial LE dipsticks has limited value in diagnosing recurrent vulvovaginal candidosis, bacterial vaginosis, and other conditions.
Supporting Evidence
- LE activity was positive in 96% of women with recurrent vulvovaginal candidosis.
- 73% of pregnant women in the second trimester had positive LE tests.
- LE activity correlated with the number of leukocytes in vaginal smears in non-pregnant women.
Takeaway
This study looked at a test that checks for inflammation in vaginal fluid, but it found that the test isn't very helpful for diagnosing certain infections.
Methodology
The study involved measuring LE activity in vaginal fluid samples from women with different conditions and correlating it with other clinical findings.
Limitations
The study may not account for all factors influencing LE activity, and the diagnostic value of LE tests was found to be limited.
Participant Demographics
The study included 113 women with recurrent vulvovaginal candidosis, 16 with vulvovaginal candidosis, 15 with bacterial vaginosis, and 73 pregnant women.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website