Analysis and validation of carbohydrate three-dimensional structures
2009
Analysis and Validation of Carbohydrate Structures
publication
Evidence: moderate
Author Information
Author(s): Thomas Lütteke
Primary Institution: Utrecht University
Hypothesis
The study aims to analyze and validate the three-dimensional structures of carbohydrates in the Protein Data Bank (PDB).
Conclusion
The article highlights the importance of validation tools in identifying errors in carbohydrate structures within the PDB.
Supporting Evidence
- About 30% of carbohydrate-containing PDB entries contain at least one error.
- Validation tools can help researchers identify problems in carbohydrate structures.
- Many glycoproteins in the PDB do not have their glycan chains resolved due to issues with crystal growth.
Takeaway
This study looks at how scientists can check if the 3D shapes of sugars in databases are correct and what problems can happen with them.
Methodology
The study reviews existing carbohydrate structures in the PDB and discusses validation tools for identifying errors.
Limitations
The study notes that many carbohydrate entries in the PDB contain errors and that validation tools are not widely used.
Digital Object Identifier (DOI)
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