Serum Antioxidant Levels in Severe Sepsis
Author Information
Author(s): Chuang Chia-Chang, Shiesh Shu-Chu, Chi Chih-Hsien, Tu Yi-Fang, Hor Lien-I, Shieh Chi-Chang, Chen Ming-Feng
Primary Institution: National Cheng Kung University, Tainan, Taiwan
Hypothesis
Does serum total antioxidant capacity (TAC) correlate with the severity of illness in patients with severe sepsis?
Conclusion
Elevated serum TAC levels may reflect the clinical severity of sepsis.
Supporting Evidence
- Serum TAC levels correlated significantly with APACHE II scores.
- Patients who died had higher TAC levels than those who survived.
- Serum uric acid levels also correlated significantly with serum TAC and APACHE II scores.
Takeaway
This study found that patients with severe sepsis have higher levels of antioxidants in their blood, which might show how serious their condition is.
Methodology
A prospective observational study measuring serum TAC, uric acid, albumin, and bilirubin in patients with severe sepsis.
Potential Biases
Potential selection bias as patients were recruited from a specific hospital.
Limitations
The study was conducted at a single center and may not be generalizable to other settings.
Participant Demographics
73 patients aged 18 and older, with a mean age of 65.9 years, including 41 men and 32 women.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI 211.7–351.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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