Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing and neuronogenic
2011
Insm1's Role in Olfactory Progenitor Development
Sample size: 12
publication
Evidence: high
Author Information
Author(s): Jason N Rosenbaum, Anne Duggan, Jaime García-Añoveros
Primary Institution: Northwestern University Feinberg School of Medicine
Hypothesis
A mammalian homolog of EGL-46 regulates transitions of progenitors from proliferative to terminally dividing and neuronogenic.
Conclusion
Insm1 promotes the transition of olfactory progenitors from apical and proliferative to basal, terminally dividing, and neuronogenic.
Supporting Evidence
- Deletion of Insm1 results in more apical cells and fewer nascent and mature neurons.
- Insm1 mutants contain fewer terminally dividing progenitors at embryonic day 12.5.
- Insm1-/- embryos exhibit a prenatal lethality that might be partially rescued by administration of L-DOPA.
Takeaway
Insm1 helps brain cells change from making more cells to becoming neurons, which are important for sensing smells.
Methodology
Generated knockout mice lacking Insm1 and analyzed their olfactory epithelium.
Limitations
The study does not explore the reasons for embryonic lethality in Insm1-/- embryos.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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