Study of Retinoid Receptors in Gastric Tissues
Author Information
Author(s): Jiang S-Y, Shen S-R, Shyu R-Y, Yu J-C, Harn H-J, Yeh M-Y, Lee M M-S, Chang Y-C
Primary Institution: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan
Hypothesis
The study investigates the expression of nuclear retinoid receptors during gastric carcinogenesis.
Conclusion
Normal gastric mucosa expressed both RARs and RXRs, while RARα expression decreased in premalignant and malignant gastric tissues, indicating its significant role in gastric cancer development.
Supporting Evidence
- Expression of RARα, RARβ, RARγ, RXRα and RXRβ was found in most cell types in gastric mucosa tissues.
- RARα and RARβ were found in three and seven cancer tissues, respectively.
- Levels of RXRα mRNA were significantly decreased in poorly differentiated cancer tissues.
- RARα mRNA expression was significantly decreased in intestinal metaplasia, dysplasia and cancer tissues compared to adjacent normal tissues.
Takeaway
The study looked at how certain receptors in the stomach change when cancer is present, finding that one important receptor decreases when cancer develops.
Methodology
In situ hybridization was used to investigate the expression of retinoic acid receptors and retinoid x receptors in gastric tissues.
Participant Demographics
Included normal individuals and gastric cancer patients.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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