Aspirin vs Direct Oral Anticoagulant for Thromboprophylaxis After Knee Replacement
Author Information
Author(s): Sumargono Endrotomo, Anastasia Maria, Singjie Leonard Christianto, Saleh Ifran, Anestessia Ira Juliet, Kholinne Erica
Primary Institution: St. Carolus Hospital, Jakarta, Indonesia
Hypothesis
There is no significant difference between aspirin and DOAC in preventing VTE after TKR procedure.
Conclusion
Aspirin is as effective as DOAC for preventing postoperative VTE after total knee replacement.
Supporting Evidence
- Aspirin and DOAC were comparable in preventing VTE in patients who underwent primary TKR.
- The incidence of deep vein thrombosis was similar in both groups (10% vs 10.1%).
- There was no significant difference in wound complications between aspirin and DOAC groups.
Takeaway
This study found that taking aspirin after knee surgery works just as well as stronger blood thinners to prevent blood clots.
Methodology
Retrospective study comparing outcomes of 476 patients who received either aspirin or DOAC for VTE prophylaxis after TKR.
Potential Biases
Potential selection and observer biases due to the single-institution study design.
Limitations
The study is retrospective, which limits the strength of evidence and may introduce selection and observer biases.
Participant Demographics
Majority female (80% in aspirin group, 81% in DOAC group); common comorbidities included hypertension.
Statistical Information
P-Value
0.98
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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