C-reactive protein predicts survival in gastro-oesophageal cancer
Author Information
Author(s): Crumley A B C, McMillan D C, McKernan M, Going J J, Shearer C J, Stuart R C
Primary Institution: University Department of Surgery, Royal Infirmary, Glasgow
Hypothesis
The study aims to examine the relationship between preoperative C-reactive protein concentration and cancer-specific survival in patients undergoing resection for gastro-oesophageal cancer.
Conclusion
An elevated preoperative C-reactive protein concentration is an independent predictor of poor cancer-specific survival in patients undergoing surgery for gastro-oesophageal cancer.
Supporting Evidence
- Patients with elevated C-reactive protein had a median survival of 19 months compared to 79 months for those with normal levels.
- The study included 120 patients who underwent surgery for gastro-oesophageal cancer.
- Fifty percent of the patients died during the follow-up period, primarily due to their disease.
Takeaway
If a patient has high levels of a protein called C-reactive protein before surgery for stomach or esophagus cancer, they might not live as long after the surgery.
Methodology
Patients selected for potentially curative resection of gastro-oesophageal cancer were included, and preoperative laboratory measurements were taken.
Potential Biases
The study may have selection bias as it only included patients who underwent surgery and did not receive neo-adjuvant treatment.
Limitations
The study is relatively small and conducted in a single center, requiring verification in larger cohorts.
Participant Demographics
The majority of patients were male, under 65 years, and had adenocarcinoma.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% CI 1.88–6.64
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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