Impact of short and long-term application of low-level laser therapy on mandibular alveolar process of osteoporotic rats – a Histological and Molecular Study
2025

Effects of Low-Level Laser Therapy on Bone Health in Osteoporotic Rats

Sample size: 40 publication Evidence: moderate

Author Information

Author(s): El-Halwagy Mai O., Hegazy Enas M., Shalaby Hany K., Mahmoud Elham F.

Primary Institution: Suez University

Hypothesis

This study aims to investigate and compare the effects of short and long-term application of low-level laser therapy on the mandibular alveolar process of osteoporotic rats.

Conclusion

Long-term application of low-level laser therapy significantly improves bone quality and organization in osteoporotic rats compared to short-term application.

Supporting Evidence

  • LLLT shows potential as a low-risk and impactful local management for osteoporosis.
  • The short-term application of laser group showed partial improvement in alveolar bone.
  • The long-term application of laser group showed dramatic positive changes in the alveolar bone.

Takeaway

Researchers studied how laser treatment helps heal bones in rats with weak bones. They found that using the laser for a longer time worked better than using it for a short time.

Methodology

The study involved 40 adult male albino rats, divided into groups receiving different treatments, including a control group, a short-term laser group, and a long-term laser group, with assessments made through histological and molecular evaluations.

Limitations

The study was conducted on rats, which may not fully represent human responses to low-level laser therapy.

Participant Demographics

Forty adult male albino rats with an average body weight of 160-180g.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1007/s10103-024-04246-1

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