Cyclin D1 Polymorphism and Endometrial Cancer Risk
Author Information
Author(s): Ashton Katie A, Proietto Anthony, Otton Geoffrey, Symonds Ian, McEvoy Mark, Attia John, Gilbert Michael, Hamann Ute, Scott Rodney J
Primary Institution: University of Newcastle, Australia
Hypothesis
Is the Cyclin D1 870 G>A polymorphism associated with an increased risk of endometrial cancer?
Conclusion
The Cyclin D1 870 G>A polymorphism may be involved in the development of endometrial cancer, particularly in relation to family history of colorectal cancer.
Supporting Evidence
- Women with the AA genotype had a higher frequency of family members with colorectal cancer.
- The study included a total of 191 endometrial cancer cases and 291 controls.
- No significant differences in genotype frequencies were observed between cases and controls.
Takeaway
This study looked at a gene change that might make women more likely to get a type of cancer called endometrial cancer, especially if their family has a history of another cancer.
Methodology
Genotyping of the Cyclin D1 870 G>A polymorphism was performed in an Australian endometrial cancer case-control population using real-time PCR analysis.
Potential Biases
Potential biases may arise from self-reported data on risk factors and the exclusion of women with breast cancer.
Limitations
The study may not be generalizable beyond the Caucasian population and had a relatively small sample size for certain analyses.
Participant Demographics
The study included 191 endometrial cancer cases and 291 controls, primarily Caucasian women.
Statistical Information
P-Value
0.045
Confidence Interval
95% CI (1.026–8.491)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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