XRCC6 Gene Polymorphisms and Papillary Thyroid Cancer in Turkey
Author Information
Author(s): Egemen AKGÜN, İÇDUYGU Fadime MUTLU, Demet ŞENGÜL, Ebru ALP, Mehmet ALKANAT, Ayşegül ÇEBİ, Tuncer ÖZTÜRK
Primary Institution: Giresun University
Hypothesis
To investigate the association between the rs2267437, rs5751129 and rs132770 polymorphisms of the XRCC6 gene and the risk of papillary thyroid carcinoma (PTC).
Conclusion
The rs2267437 polymorphism may have a protective effect against PTC in the Turkish population, while the rs5751129 and rs132770 polymorphisms were not associated with the disease.
Supporting Evidence
- Individuals with the GG genotype had a lower risk of PTC than those with the CC genotype.
- The combined genotypes CG+GG were related to a reduced risk of PTC compared to the CC genotype.
- The rs2267437 polymorphism may alter the expression level of XRCC6 in whole blood.
Takeaway
This study looked at how certain gene changes might affect the risk of thyroid cancer, finding that one specific change could help protect against it.
Methodology
The study included 150 patients with PTC and 204 healthy controls, using PCR-RFLP for genotyping.
Limitations
Moderate sample size and lack of an expression study.
Participant Demographics
150 individuals with thyroid cancer and 204 healthy controls, with no history of cancer.
Statistical Information
P-Value
p = 0.037
Confidence Interval
95% CI: 0.19–0.96
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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