Statins and Heart Health: How They Help Blood Vessel Growth
Author Information
Author(s): Wang Wen, Lang Jennifer K., Suzuki Gen, Canty John M. Jr, Cimato Thomas
Primary Institution: Department of Medicine/Cardiovascular Medicine, School of Medicine and Biomedical Sciences, SUNY at Buffalo
Hypothesis
Statins exert positive effects on the mobilization and growth of late outgrowth endothelial progenitor cells, and capillary density in ischemic heart tissue.
Conclusion
Statins promote the growth of late outgrowth endothelial progenitor cells and increase capillary density in the chronically ischemic heart.
Supporting Evidence
- Pravastatin therapy resulted in a greater than two-fold increase in CD31+ late outgrowth endothelial progenitor cells.
- Pravastatin increased capillary density by 46% in animals with chronic myocardial ischemia.
- Both pravastatin and simvastatin increased the number of late outgrowth endothelial progenitor cells greater than three-fold in culture.
Takeaway
Statins are like helpers for your heart; they help grow new blood vessels when the heart is not getting enough blood.
Methodology
The study involved treating pigs with pravastatin and measuring the effects on late outgrowth endothelial progenitor cells and capillary density.
Limitations
The study was conducted on young pigs, and results may not directly translate to humans.
Participant Demographics
Eight healthy pigs, aged 11-14 weeks, with a weight of approximately 40 kg.
Statistical Information
P-Value
p≤0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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