Epigenetic reprogramming of host genes in viral and microbial pathogenesis
2010
How Viruses and Bacteria Change Host Genes
Sample size: 212
publication
Evidence: moderate
Author Information
Author(s): Paschos Konstantinos, Allday Martin J.
Primary Institution: Imperial College London
Hypothesis
Pathogens associated with the development of cancer might initiate or influence the epigenetic processes of host cells, leading to epigenetic reprogramming.
Conclusion
Pathogens can manipulate host epigenetic processes, which may contribute to chronic diseases and cancer.
Supporting Evidence
- Viruses like KSHV and EBV can induce epigenetic changes in host cells.
- Chronic infections by bacteria such as H. pylori are linked to cancer development.
- Epigenetic changes can lead to the silencing of tumor suppressor genes.
Takeaway
Some germs can change how our genes work, which might make us sick or even cause cancer.
Methodology
The article reviews examples of epigenetic control of host genes by viral and bacterial pathogens.
Limitations
The review does not cover all possible epigenetic changes or mechanisms involved.
Digital Object Identifier (DOI)
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