Cold Storage and Kidney Transplants from Pigs to Baboons
Author Information
Author(s): Yamada Kazuhiko, Hisadome Yu, Eisenson Daniel, Chen WeiLi, Schulick Alex, Santillan Michelle, Luo Adam, Casella Kelly, Gu Du, Sekijima Mitsuhiro, Sahara Hisashi, Warren Daniel, Cameron Andrew, Iwase Hayato, Shenderov Eugene
Hypothesis
Does the method of kidney preservation affect early graft function in pig-to-baboon xenotransplantation?
Conclusion
Cold storage of pig kidneys leads to early graft loss, while hypothermic machine perfusion may help prevent this issue.
Supporting Evidence
- The study involved eight cases of pig-to-baboon xenotransplantation after five hours of cold ischemic time.
- Six additional cases were performed with minimal ischemic time for comparison.
- Porcine kidneys are sensitive to injury after cold preservation.
- Routine static cold storage can lead to hyperacute graft loss.
Takeaway
Storing pig kidneys in cold conditions can cause them to fail quickly when transplanted into baboons, but using a special machine to keep them cold might help them work better.
Methodology
The study involved comparing outcomes of pig-to-baboon xenotransplantation with different kidney preservation strategies.
Participant Demographics
The study involved pig-to-baboon xenotransplantation cases.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website