Skin Invasion and Prognosis in Node Negative Breast Cancer
Author Information
Author(s): Tada Keiichiro, Morizono Hidetomo, Iijima Kotaro, Miyagi Yumi, Nishimura Seiichiro, Makita Masujiro, Horii Rie, Akiyama Futoshi, Iwase Takuji
Primary Institution: Cancer Institute Hospital, Tokyo, Japan
Hypothesis
What is the impact of skin invasion on the prognosis of node negative breast cancer patients?
Conclusion
Skin invasion has no impact on survival in node negative invasive breast cancer patients.
Supporting Evidence
- Patients with skin invasion had a 5-year disease-free survival rate of 94.0%.
- The 10-year disease-specific overall survival rates were 90.7% for the case group and 92.9% for the control group.
- Older patients and larger tumor sizes were more common in the case group.
- Invasive lobular carcinoma was more prevalent in the case group.
Takeaway
This study found that having skin invasion in breast cancer doesn't change how long patients live after treatment.
Methodology
The study analyzed 97 node negative breast cancer patients with skin invasion and compared them to a control group of 4500 node negative patients.
Potential Biases
The retrospective nature may introduce bias in survival status reporting.
Limitations
The study is retrospective, has a small sample size, and does not include strictly T4 tumors.
Participant Demographics
The case group included 96 women and 1 man, with a mean age of 58.8 years.
Statistical Information
P-Value
0.2032
Statistical Significance
p = 0.2032
Digital Object Identifier (DOI)
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