Functional Limitations and Mortality in Aging People with HIV and Substance Use
Author Information
Author(s): Ramamurthi Hema, Gruber-Baldini Ann, Orwig Denise
Primary Institution: Johns Hopkins University
Hypothesis
The study investigates the impact of HIV, substance use, and functional limitations on survival among aging individuals.
Conclusion
Self-reported functional limitations and other modifiable risk factors are important predictors of mortality among people living with HIV.
Supporting Evidence
- Aging individuals living with HIV experience earlier onset of adverse health outcomes.
- PLWH had a higher prevalence of functional limitations compared to HIV-negative individuals.
- Detectable viral load and functional limitations were predictive of mortality.
Takeaway
Older people with HIV who have trouble doing physical activities are more likely to have serious health problems and die sooner.
Methodology
The study analyzed longitudinal data from biannual visits of participants in the ALIVE cohort from 2005 to 2020.
Participant Demographics
The sample included 751 people living with HIV, who were slightly older than HIV-negative individuals.
Statistical Information
P-Value
p<0.001
Confidence Interval
CI=2.08-2.97; CI=1.07-1.50; CI=1.51-2.10
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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