Sinomenine's Role in Protecting Brain Cells from Alzheimer's Damage
Author Information
Author(s): Shilpa Mishra Shukla, Shiv K Sharma
Primary Institution: National Brain Research Centre, Manesar, Haryana, India
Hypothesis
Does sinomenine prevent microglial activation and neurotoxicity induced by amyloid-β?
Conclusion
Sinomenine prevents microglial activation and protects hippocampal cells from indirect neurotoxicity caused by amyloid-β.
Supporting Evidence
- Sinomenine reduces levels of reactive oxygen species and nitric oxide in microglial cells.
- Sinomenine protects hippocampal HT22 cells from indirect toxicity mediated by Aβ-treated microglial cells.
- Sinomenine inhibits the release of inflammatory molecules induced by oligomeric Aβ.
Takeaway
Sinomenine is a natural compound that helps protect brain cells from damage caused by a harmful protein linked to Alzheimer's disease.
Methodology
The study involved treating BV2 microglial cells and hippocampal HT22 cells with sinomenine and oligomeric amyloid-β, followed by various assays to measure reactive oxygen species, nitric oxide, and cell viability.
Limitations
Sinomenine did not protect against direct toxicity from amyloid-β in hippocampal cells.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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