Cerebral Cortical Changes in Craniosynostosis: A Systematic Review
Author Information
Author(s): Muacevic Alexander, Adler John R, Palaios Michail, Rapanos Christos, Kapsokavadis Ioannis, Katouni Kyriaki, Filippou Dimitrios
Primary Institution: Department of Anatomy, National and Kapodistrian University of Athens School of Medicine
Hypothesis
This study aims to review the existing literature on cerebral cortical changes in craniosynostosis.
Conclusion
Craniosynostosis is associated with changes in the brain cortex’s thickness, surface area, connectivity between different regions of the brain, and the morphology of fissures and gyri.
Supporting Evidence
- Craniosynostosis occurs in one out of 2,000-2,500 births.
- Syndromic craniosynostosis is often caused by mutations in the FGFR genes.
- Non-syndromic craniosynostosis is seen in roughly one per 1000 live births.
- Surgery is the most common treatment for craniosynostosis.
- Patients with craniosynostosis may experience various developmental complications.
Takeaway
Craniosynostosis can change how the brain grows and connects, which can lead to problems with thinking and learning.
Methodology
A systematic search of the PubMed database was performed, retrieving 50 articles, of which 16 were included after applying selection and exclusion criteria.
Potential Biases
The quality assessment of the included studies indicated low risk of bias in most domains.
Limitations
The existing data are not sufficient to resolve the dilemma between the deformation theory and malformation theory regarding craniosynostosis.
Participant Demographics
The review included studies on both syndromic and non-syndromic craniosynostosis.
Digital Object Identifier (DOI)
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