Understanding Tissue-Nonspecific Alkaline Phosphatase and Its Functions
Author Information
Author(s): Imam Iliass, Rautureau Gilles Jean Philippe, Violot Sébastien, Drevet Mulard Eva, Magne David, Ballut Lionel
Primary Institution: Molecular Microbiology and Structural Biochemistry, UMR 5086, CNRS, University Lyon, France
Hypothesis
What are the structural and functional roles of tissue-nonspecific alkaline phosphatase (TNAP) within the alkaline phosphatase superfamily?
Conclusion
The review highlights the multifunctionality of TNAP and its evolutionary significance within the alkaline phosphatase superfamily.
Supporting Evidence
- TNAP is crucial for bone mineralization by hydrolyzing inorganic pyrophosphate.
- Mutations in the ALPL gene lead to hypophosphatasia, affecting bone mineralization.
- TNAP has roles in dephosphorylating pyridoxal phosphate, impacting vitamin B6 metabolism.
- Recent studies suggest TNAP's involvement in adaptive thermogenesis.
Takeaway
Tissue-nonspecific alkaline phosphatase helps our bodies use important nutrients and minerals, and this study looks at how it works and why it's important.
Methodology
The review compares the sequence, structure, and evolutionary trajectory of TNAP with other members of the alkaline phosphatase superfamily.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website