PHOG: A Database of Supergenomes from Proteome Complements
Author Information
Author(s): Merkeev Igor V, Novichkov Pavel S, Mironov Andrey A
Primary Institution: State Scientific Center GosNIIGenetica
Hypothesis
Can we automate the creation of clusters of orthologous groups from sequenced genomes using a rigorous evolutionary approach?
Conclusion
The PHOG database shows that it is feasible to automatically process sequenced genomes to reconstruct orthologous and paralogous relationships.
Supporting Evidence
- The procedure can process any number of sequenced genomes.
- 51367 PHOGs were obtained at the root node of the taxonomy tree.
- The database can be used in various areas of comparative genomics.
Takeaway
The PHOG database helps scientists understand how genes from different organisms are related by grouping them based on their evolutionary history.
Methodology
An automated procedure was developed to create clusters of orthologous groups at each node of the taxonomy tree using protein complements from various species.
Limitations
The study may be limited by the accuracy of the taxonomy tree and the completeness of the sequenced genomes used.
Digital Object Identifier (DOI)
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