Serum IGF-1 and IGFBP-3 Levels in Healthy Children
Author Information
Author(s): Yüksel Bilgin, Özbek M. Nuri, Mungan Neslihan Önenli, Darendeliler Feyza, Budan Bahar, Bideci Aysun, Çetinkaya Ergün, Berberoğlu Merih, Evliyaoğlu Olcay, Yeşilkaya Ediz, Arslanoğlu İlknur, Darcan Şükran, Bundak Ruveyda, Ercan Olcay
Primary Institution: Cukurova University, Faculty of Medicine, Pediatric Endocrinology and Metabolism, Adana, Turkey
Hypothesis
The study aimed to establish reference values for serum IGF-1 and IGFBP-3 in healthy Turkish children less than 6 years of age.
Conclusion
The age- and gender-specific reference values for serum IGF-1 and IGFBP-3 reported in this study will aid in the diagnosis of GH deficiency and in the monitoring of children receiving GH treatment.
Supporting Evidence
- The study included 567 healthy children under 6 years of age.
- Serum IGF-1 levels showed a slow increase with age.
- Lower IGF-1 levels were observed in girls compared to boys at 6 months.
- No correlation was found between IGFBP-3 levels and BMI.
- A weak correlation was observed between serum IGF-1 and IGFBP-3 concentrations.
- Reference values established can aid in diagnosing GH deficiency.
- Statistical analyses were performed using SPSS.
- Ethics approval was obtained from the Cukurova University Ethics Committee.
Takeaway
This study looked at healthy kids under 6 years old to find out what normal levels of certain growth hormones should be.
Methodology
The study was a multicenter project involving 567 healthy children under 6 years, measuring serum IGF-1 and IGFBP-3 levels along with anthropometric parameters.
Potential Biases
Potential selection bias due to exclusion of children with recent infections.
Limitations
The study may not account for all confounding factors affecting IGF-1 and IGFBP-3 levels.
Participant Demographics
310 boys and 256 girls from different geographical regions of Turkey.
Statistical Information
P-Value
0.012
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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