Th2 cells and cytokine networks in allergic inflammation of the lung
1995
Cytokines and Th2 Cells in Asthma
publication
Author Information
Author(s): Anthony J. Coyle, Shogo Tsuyuki
Primary Institution: Asthma and Allergy Research Department, CIBA-GEIGY AG, Basel, Switzerland; Dept. of Research, Kissei Pharmaceutical, Matsumoto, Japan
Hypothesis
Cytokines released from Th2 and Th2-like cells are central to the pathophysiology of asthma and allergy.
Conclusion
Th2 inhibitors may prove to be novel therapies for the treatment of bronchial asthma due to the central role of IL-4 in asthma pathology.
Supporting Evidence
- IL-4 is a central target for B cell IgE production.
- Th2 cells are involved in eosinophilic inflammation.
- Glucocorticoids are unable to modify many IL-4 dependent effects.
Takeaway
This study talks about how certain cells in our body, called Th2 cells, release substances that can cause asthma and allergies. Finding ways to block these substances might help treat asthma better.
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