Impact of Extranodal Involvement on Survival in Stage IV Diffuse Large B-Cell Lymphoma
Author Information
Author(s): Kim Tong‐Yoon, Kim Tae‐Jung, Han Eun Ji, Min Gi June, Park Sung‐Soo, Park Silvia, Yoon Jae‐Ho, Lee Sung‐Eun, Cho Byung‐Sik, Eom Ki‐Seong, Kim Yoo‐Jin, Kim Hee‐Je, Lee Seok, Min Chang‐Ki, Lee Jong‐Wook, Jeon Youngwoo, Cho Seok‐Goo
Primary Institution: Yeouido St. Mary's Hospital, College of Medicine The Catholic University of Korea
Hypothesis
How do different extranodal sites affect prognosis in young patients with stage IV diffuse large B-cell lymphoma who achieved complete remission after treatment?
Conclusion
Specific extranodal sites significantly influence the prognosis of patients with stage IV diffuse large B-cell lymphoma, with patients having spleen involvement benefiting from autologous stem cell transplantation.
Supporting Evidence
- Patients with a Deauville score of 3 had significantly lower survival rates.
- Nasosinusal involvement was a significant predictor of reduced overall survival.
- Patients with spleen involvement showed improved progression-free survival with ASCT.
Takeaway
This study found that where the cancer spreads in the body can change how well patients do, especially if it spreads to the spleen.
Methodology
A bicenter retrospective study analyzing data from patients with DLBCL aged <60 years who achieved complete remission after chemo-immunotherapy.
Potential Biases
Potential biases due to the retrospective nature of the study and selection criteria.
Limitations
The study is retrospective and includes only patients under 60 years, limiting generalizability to older populations.
Participant Demographics
Patients aged <60 years with stage IV diffuse large B-cell lymphoma.
Statistical Information
P-Value
0.014
Confidence Interval
1.22–5.91
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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