α-Mangostin Reduces Tumor Growth in Breast Cancer Model
Author Information
Author(s): Shibata Masa-Aki, Iinuma Munekazu, Morimoto Junji, Kurose Hitomi, Akamatsu Kanako, Okuno Yasushi, Akao Yukihiro, Otsuki Yoshinori
Primary Institution: Osaka Health Science University
Hypothesis
Does α-mangostin have antitumor and antimetastatic effects in a mouse model of metastatic mammary cancer with a p53 mutation?
Conclusion
α-Mangostin significantly increases survival and reduces tumor growth and lymph node metastasis in a mouse model of breast cancer.
Supporting Evidence
- In vivo survival rates were significantly higher in the 20 mg/kg/day α-mangostin group versus controls.
- Tumor volume and lymph node metastases were significantly suppressed in the α-mangostin treated groups.
- Apoptotic levels were significantly increased in the mammary tumors of mice receiving 20 mg/kg/day.
- α-Mangostin treatment decreased microvessel density and the number of dilated lymphatic vessels containing tumor cells.
Takeaway
This study found that a compound from mangosteen fruit can help stop cancer from growing and spreading in mice.
Methodology
Mice with mammary tumors were treated with α-mangostin at varying doses, and tumor growth and metastasis were measured.
Limitations
The study was conducted in a mouse model, which may not fully replicate human responses.
Participant Demographics
Female BALB/c mice, 36 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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