Eukaryotic initiation factor-4E and bladder cancer
Author Information
Author(s): Crew J P, Fuggle S, Bicknell R, Cranston D W, Benedetti A de, Harris A L
Primary Institution: The Molecular Angiogenesis Group, Imperial Cancer Research Fund, The Institute of Molecular Medicine, Oxford, UK
Hypothesis
The study investigates the role of eIF-4E in regulating VEGF expression in bladder cancer.
Conclusion
eIF-4E may play a role in the translational regulation of VEGF and could serve as a prognostic factor in bladder cancer.
Supporting Evidence
- VEGF mRNA expression was threefold higher in superficial compared to muscle invasive bladder cancers.
- VEGF protein levels correlated with mRNA expression in normal bladder and bladder cancer.
- High expression of eIF-4E was associated with poor prognosis in superficial tumours.
Takeaway
This study found that a protein called eIF-4E is important for how bladder cancer cells grow and could help doctors predict how patients will do.
Methodology
VEGF mRNA and protein levels were measured in normal bladder and primary bladder cancers.
Participant Demographics
Normal bladder (n = 12) and primary bladder cancers (n = 57).
Statistical Information
P-Value
P = 0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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