How Nanoparticle Surface Charge Affects Tumor Uptake
Author Information
Author(s): Arvizo Rochelle R., Miranda Oscar R., Moyano Daniel F., Walden Chad A., Giri Karuna, Bhattacharya Resham, Robertson J. David, Rotello Vincent M., Reid Joel M., Mukherjee Priyabrata
Primary Institution: Mayo Clinic Rochester
Hypothesis
The neutral and zwitterionic nanoconjugates would exhibit increased tumor uptake relative to negative and positively charged analogs.
Conclusion
Neutral and zwitterionic nanoparticles demonstrated longer circulation time and enhanced tumor uptake compared to negatively and positively charged nanoparticles.
Supporting Evidence
- Neutral and zwitterionic nanoparticles had longer circulation times.
- Negatively and positively charged nanoparticles had shorter half-lives.
- Tumor uptake was enhanced by neutral and zwitterionic nanoparticles.
- The study used a family of structurally homologous nanoparticles.
Takeaway
Some tiny particles can help medicine get to the right place in the body better than others, depending on how they are made.
Methodology
The study involved injecting different types of nanoparticles into mice and measuring their circulation time and tumor uptake.
Limitations
The study primarily focused on a specific type of nanoparticle and may not generalize to all nanoparticles.
Participant Demographics
Male CD1 mice and athymic nude mice were used in the experiments.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website