Effect of Domperidone on Breast Milk Composition
Author Information
Author(s): Marsha L Campbell-Yeo, Alexander C Allen, Joseph K S Joseph, Joyce M Ledwidge, Victoria M Allen, Kent C Dooley
Primary Institution: IWK Health Centre and Dalhousie University
Hypothesis
The macronutrient composition (protein, fat and calories) of human breast milk will be significantly altered by the administration of domperidone.
Conclusion
Domperidone may significantly change the nutrient content of breast milk, which could impact feeding practices for preterm infants.
Supporting Evidence
- Domperidone has been shown to safely increase the milk supply of lactating women.
- Current guidelines for fortification of human milk for premature infants do not distinguish between those using or not using domperidone.
- Significant changes in nutrient content of breast milk could necessitate alterations in feeding practices for preterm infants.
Takeaway
This study looks at how a medicine called domperidone affects the nutrients in breast milk for mothers of premature babies. If it helps make the milk better, it could change how we feed these babies.
Methodology
Mothers of infants delivered at less than 31 weeks gestation will be randomized to receive domperidone or placebo for 14 days, with breast milk samples collected for analysis.
Potential Biases
Potential biases may arise from the double-blind design, but randomization aims to mitigate these risks.
Limitations
The study may not account for all variables affecting breast milk composition, and the sample size is relatively small.
Participant Demographics
Mothers of very preterm infants (less than 31 weeks gestation) who are at least 3 weeks postpartum.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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