NADPH Oxidase Subunit 4 and Tumor Progression in Glioblastoma
Author Information
Author(s): Hsieh Chia-Hung, Shyu Woei-Cherng, Chiang Chien-Yi, Kuo Jung-Wen, Shen Wu-Chung, Liu Ren-Shyan
Primary Institution: China Medical University and Hospital
Hypothesis
Nox4 is a critical mediator of cycling hypoxia-mediated ROS generation and tumor progression in glioblastoma.
Conclusion
Cycling hypoxia-induced ROS via Nox4 is a critical aspect of cancer biology to consider for therapeutic targeting of HIF-1 activation and tumor progression in GBM.
Supporting Evidence
- Cycling hypoxia increased ROS production and HIF-1 activation in glioblastoma cells.
- Nox4 knockdown inhibited cycling hypoxia-induced effects.
- Tempol treatment reduced ROS levels and tumor growth in vivo.
Takeaway
This study found that low oxygen levels in tumors can make them grow faster by producing harmful molecules, and blocking these molecules could help treat brain cancer.
Methodology
Glioblastoma cell lines were exposed to cycling hypoxic stress in vitro and in vivo, with ROS production measured through various assays.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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