Direct Transition from Vesicles to Cubosomes in Monoelaidin Aqueous Dispersions
Author Information
Author(s): Yaghmur Anan, Laggner Peter, Almgren Mats, Rappolt Michael
Primary Institution: Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences, Graz, Austria
Hypothesis
Is it possible to induce a direct transition of vesicles to cubosomes by heating a ME-based aqueous dispersion?
Conclusion
The study reveals that a direct liposomes-cubosomes transition in ME dispersion is possible, influenced significantly by the polymeric stabilizer F127.
Supporting Evidence
- The study demonstrated that the polymeric stabilizer F127 plays a significant role in the membrane fusion processes.
- SAXS findings indicated a direct Lα-V2 internal transition in the dispersion.
- Cryo-TEM observations revealed the formation of closely packed onion-like vesicles at 25°C.
- Above 65°C, flattened cubosomes with an internal nanostructure were observed.
Takeaway
This study shows that by heating a special mixture, we can change tiny blobs of fat (vesicles) into a different shape (cubosomes) that can hold more water, which is important for making medicines.
Methodology
The study used synchrotron small-angle X-ray scattering (SAXS) and Cryo-TEM to characterize the structural transitions of monoelaidin aqueous dispersion.
Limitations
The dispersions were significantly less stable than those based on monoolein, losing stability within days.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website