Somatostatin Receptors in the Cochlea
Author Information
Author(s): Radojevic Vesna, Hanusek Claudia, Setz Cristian, Brand Yves, Kapfhammer Josef P, Bodmer Daniel
Primary Institution: University Hospital Basel
Hypothesis
The somatostatinergic system has a protective effect on hair cell loss in the cochlea.
Conclusion
Somatostatin receptors are specifically expressed in hair cells and supporting cells of the mouse cochlea, and the absence of SST1 alters the expression of SST2.
Supporting Evidence
- The study demonstrated that SST1 and SST2 receptors are expressed in outer and inner hair cells.
- Immunohistochemistry confirmed the presence of SST1 and SST2 in cochlear tissues.
- Absence of SST1 led to altered expression patterns of SST2 in supporting cells.
Takeaway
This study found that certain receptors in the ear help protect hearing cells, and if one type of receptor is missing, another type changes how it works.
Methodology
Real-time PCR and immunohistochemistry were used to analyze the expression of somatostatin receptors in cochlear tissues from wild-type and knockout mice.
Limitations
The study primarily focused on mouse models, which may not fully represent human physiology.
Participant Demographics
Wild-type and knockout mice of both sexes were used.
Statistical Information
P-Value
p<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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