Resveratrol interferes with AKT activity and triggers apoptosis in human uterine cancer cells
2006
Resveratrol's Effects on Uterine Cancer Cells
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Émilie Sexton, Céline Van Themsche, Kim Leblanc, Sophie Parent, Pascal Lemoine, Eric Asselin
Primary Institution: Université du Québec à Trois-Rivières
Hypothesis
Resveratrol could exert tumoricidal activity over uterine cancer cells upon inhibition of COX-2 expression and/or activity.
Conclusion
High-dose of resveratrol exerts tumoricidal activity over uterine cancer cells and regulates COX expression.
Supporting Evidence
- High-dose of resveratrol triggered apoptosis in five out of six uterine cancer cell lines.
- Resveratrol reduced cellular levels of the phosphorylated/active form of anti-apoptotic kinase AKT.
- Endogenous COX-2 protein levels were decreased in uterine cancer cells treated with resveratrol.
Takeaway
Resveratrol, a compound found in red wine, can kill certain cancer cells in the uterus and change how some proteins work in those cells.
Methodology
The study used six different human uterine cancer cell lines and assessed the effects of resveratrol on apoptosis and COX expression.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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