Study of Primary Intestinal Non-Hodgkin Lymphoma in 581 Patients
Author Information
Author(s): Kim Seok Jin, Choi Chul Won, Mun Yeung-Chul, Oh Sung Yong, Kang Hye Jin, Lee Soon Il, Won Jong Ho, Kim Min Kyoung, Kwon Jung Hye, Kim Jin Seok, Kwak Jae-Yong, Kwon Jung Mi, Hwang In Gyu, Kim Hyo Jung, Lee Jae Hoon, Oh Sukjoong, Park Keon Woo, Suh Cheolwon, Kim Won Seog
Primary Institution: Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Hypothesis
What are the clinical features and survival outcomes of patients with primary intestinal non-Hodgkin lymphoma?
Conclusion
Patients with ileocecal region involvement had better survival outcomes than those with involvement at other sites.
Supporting Evidence
- B-cell lymphoma was more frequent than T-cell lymphoma (86.7% vs 13.3%).
- Patients with T-cell lymphoma had a significantly lower 5-year overall survival rate (28%) compared to B-cell lymphoma (71%).
- Surgical resection improved overall survival rates in patients with B-cell lymphomas.
- Age > 60 years and poor performance status were independent prognostic factors for survival.
Takeaway
This study looked at a lot of patients with a type of cancer in the intestines and found that where the cancer is located can affect how well people do.
Methodology
Retrospective analysis of clinical data from 581 patients diagnosed with primary intestinal NHL across 16 hospitals in Korea.
Potential Biases
Potential biases due to the retrospective nature of the study and exclusion of certain diagnostic methods.
Limitations
The study is retrospective and may not include all patients diagnosed consecutively.
Participant Demographics
Median age was 56 years, with a male to female ratio of 1.71:1.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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