Using Acellular Corneal Stroma in Corneal Transplant Surgery
Author Information
Author(s): Li Naiyang, Wang Xiaoran, Wan Pengxia, Huang Minghai, Wu Zheng, Liang Xuanwei, Liu Ying, Ge Jian, Huang Junqi, Wang Zhichong
Primary Institution: Sun Yat-sen University
Hypothesis
Acellular corneal stroma (ACS) can be used in tectonic lamellar keratoplasty (TLKP) to improve transplant survival in high-risk corneal transplantation.
Conclusion
The use of ACS for TLKP prolonged the survival of corneal transplants and reduced neovascularization and inflammatory cell infiltration.
Supporting Evidence
- The mean survival time of transplants in the ACS group was 36.4 days compared to 14.0 days in the control group.
- The ACS group showed significantly smaller neovascularization areas after two and four weeks compared to the control group.
- Histology revealed fewer inflammatory cells in the ACS group than in the control group.
Takeaway
This study shows that using a special type of cornea without cells can help eye surgeries work better and last longer.
Methodology
The study involved 28 rabbits receiving either ACS or fresh corneal lamella for TLKP, followed by central optical PKP, with outcomes assessed post-operatively.
Participant Demographics
New Zealand white rabbits, aged 10 weeks, weighing 2–3 kg.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
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