Krill Oil Reduces 2-Arachidonoylglycerol Levels in Obese People
Author Information
Author(s): Banni Sebastiano, Carta Gianfranca, Giacarta, Murru Elisabetta, Cordeddu Lina, Giordano Elena, Sirigu Anna Rita, Berge Kjetil, Vik Hogne, Maki Kevin C, Di Marzo Vincenzo, Griinari Mikko
Primary Institution: Dipartimento Biologia Sperimentale, Università di Cagliari
Hypothesis
Does krill oil intake affect plasma endocannabinoid levels in overweight and obese subjects?
Conclusion
Krill oil significantly decreases plasma 2-arachidonoylglycerol levels in obese subjects.
Supporting Evidence
- Krill oil was more effective than menhaden oil or olive oil in reducing 2-AG levels.
- Obese subjects had higher baseline levels of endocannabinoids compared to normoweight subjects.
- The decrease in 2-AG was correlated with the n-6/n-3 phospholipid ratio.
Takeaway
Taking krill oil can help lower certain fat levels in the blood of people who are overweight or obese.
Methodology
A 4-week, randomized, double-blind, controlled trial with 63 participants assigned to different oil treatments.
Potential Biases
Potential bias due to the involvement of authors with ties to the krill oil industry.
Limitations
The study had a small number of male participants and did not assess fat distribution in obese subjects.
Participant Demographics
63 generally healthy men and women aged 35 to 64, with waist circumference indicating obesity.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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