Comparative Absorption and Bioavailability of Various Chemical Forms of Zinc in Humans
Author Information
Author(s): Devarshi Prasad P., Mao Qingqing, Grant Ryan W., Hazels Mitmesser Susan, Swain James H.
Primary Institution: Pharmavite, LLC
Hypothesis
Different chemical forms of zinc have varying levels of absorption and bioavailability in humans.
Conclusion
Zinc glycinate and zinc gluconate are better absorbed than other forms of zinc.
Supporting Evidence
- Zinc glycinate significantly increased plasma zinc levels compared to baseline.
- Zinc picolinate significantly increased zinc levels in hair, urine, and erythrocytes.
- Zinc gluconate was better absorbed than zinc oxide in one study.
Takeaway
Zinc is important for our health, and some types of zinc supplements work better in our bodies than others.
Methodology
A literature search was conducted to identify studies comparing the absorption/bioavailability of two or more forms of zinc in humans, including observational studies and clinical trials.
Potential Biases
Most studies included only one sex, which may affect plasma zinc concentrations.
Limitations
The small number of studies per zinc form and heterogeneity in assessing zinc levels limit the findings.
Participant Demographics
The studies included young adult women and healthy individuals.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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