Butyrate Improves Liver Glycogen Storage in Rats
Author Information
Author(s): Beauvieux Marie-Christine, Roumes Hélène, Robert Nadège, Gin Henri, Rigalleau Vincent, Gallis Jean-Louis
Primary Institution: Centre de Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS-UB2
Hypothesis
Does butyrate influence hepatic glycogen storage and ATP metabolism in rats?
Conclusion
Butyrate ingestion enhances liver glycogen storage and ATP levels in re-fed rats.
Supporting Evidence
- Butyrate increased glycogen synthesis rate compared to glucose alone.
- The maximal glycogen content was significantly higher with butyrate.
- Butyrate delayed the equilibrium between glycogen synthesis and breakdown.
Takeaway
When rats eat butyrate along with glucose, their liver stores more sugar for later use, which is good for their energy levels.
Methodology
Rats were fasted for 48 hours and then force-fed with glucose alone or glucose plus butyrate, with liver glycogen and ATP measured using NMR.
Limitations
The study was conducted in rats, and results may not directly translate to humans.
Participant Demographics
Male Wistar rats, weighing 90–120 g.
Statistical Information
P-Value
P = 0.003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website