Gene Polymorphisms and Gastric Cancer Risk
Author Information
Author(s): Kupcinskas Juozas, Wex Thomas, Bornschein Jan, Selgrad Michael, Leja Marcis, Juozaityte Elona, Kiudelis Gediminas, Jonaitis Laimas, Malfertheiner Peter
Primary Institution: Lithuanian University of Health Sciences
Hypothesis
Are gene polymorphisms of ACE, NOD1, TLR4, and FAS/FASL associated with gastric cancer and premalignant gastric lesions in Caucasians?
Conclusion
The study found no significant associations between the examined gene polymorphisms and gastric cancer or high risk atrophic gastritis in Caucasians.
Supporting Evidence
- No significant associations were found for ACE, NOD1, TLR4, and FAS/FASL gene polymorphisms with gastric cancer.
- The study included 574 subjects, with 114 having gastric cancer and 222 with high risk atrophic gastritis.
- Genotyping was performed using PCR and restriction fragment length polymorphism analysis.
Takeaway
The researchers looked at certain genes to see if they could help predict stomach cancer, but they found that these genes don't seem to be linked to the disease.
Methodology
Gene polymorphisms were analyzed in 574 subjects using PCR and restriction fragment length polymorphism analysis.
Limitations
The study may not account for all genetic factors influencing gastric cancer risk and was limited to Caucasian subjects.
Participant Demographics
Participants were of Caucasian origin, including patients with gastric cancer, high risk atrophic gastritis, and healthy controls.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website