ER81 Expression in Breast Cancers and Hyperplasia
Author Information
Author(s): Wang YuanYuan, Wang Li, Chen Yue, Li Lin, Yang XuanTao, Li BaoLin, Song ShuLing, Yang LiLin, Hao Yan, Yang JuLun
Primary Institution: Kunming General Hospital/Kunming Medical College
Hypothesis
To investigate the role of ER81 in breast carcinogenesis.
Conclusion
ER81 overexpression may play an important role in breast carcinogenesis.
Supporting Evidence
- ER81 overexpression was detected in 63.0% of invasive ductal carcinomas.
- Statistical significance was found between normal breast tissues and hyperplasia of usual type.
- ER81 expression was significantly associated with Her2 amplification.
Takeaway
This study looked at a protein called ER81 in different types of breast tissue to see if it helps cancer grow. They found that more cancerous tissues had higher levels of this protein.
Methodology
Immunohistochemical staining was used to examine ER81 expression in various breast tissues.
Limitations
The study may not account for all factors influencing ER81 expression and its role in breast cancer.
Participant Demographics
Tissue specimens were collected from patients with various breast conditions, including invasive ductal carcinoma and ductal carcinoma in situ.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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