Venous gangrene and cancer: A cool look at a burning issue
2007

Venous Gangrene and Cancer

Sample size: 1041 publication Evidence: moderate

Author Information

Author(s): Osman Khalid A, Ahmed Mohamed H, Abdulla Samir A, Bucknall Tim E, Rogers Colin A

Primary Institution: Department of Surgery, Queen's Hospital, Burton Hospitals NHS Trust, Staffordshire, UK

Hypothesis

The presence of anticardiolipin antibodies increases the risk of venous gangrene in cancer patients.

Conclusion

Venous gangrene is rare in cancer patients but is associated with a complex pathogenesis involving hypercoagulable states and various risk factors.

Supporting Evidence

  • Venous gangrene is associated with poor prognosis in cancer patients.
  • Anticardiolipin antibodies double the risk of thrombo-embolic events in cancer patients.
  • LMWH is suggested as a safe and effective treatment for venous thromboembolism in cancer patients.

Takeaway

Venous gangrene is a serious condition that can happen to cancer patients, and certain treatments can help prevent it.

Methodology

Review of existing literature and case studies on venous gangrene in cancer patients.

Limitations

The incidence of venous gangrene in cancer patients is not well established, and further research is needed.

Participant Demographics

Patients with solid tumors, particularly those with advanced malignancies.

Digital Object Identifier (DOI)

10.1186/1477-7800-4-7

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