Validation of 125I-hCG as a marker for elimination of hCG and stability of 125I-hCG after in vivo injection in humans
1999
Using 125I-hCG to Track hCG Levels in Cancer Patients
Sample size: 13
publication
Evidence: moderate
Author Information
Author(s): Christensen T B, Marqversen J, Engbaek F, Berger P, Bacher T, Maase H von der
Primary Institution: Aarhus University Hospital, Denmark
Hypothesis
Is 125I associated with hCG after intravenous injection in humans?
Conclusion
The study found that 125I-hCG can be used to track the elimination of hCG in humans for up to 28 days after injection.
Supporting Evidence
- The study tracked the elimination of hCG using 125I-hCG in 13 normal subjects.
- The disappearance of radioactivity and hCG showed identical paths over 28 days.
- The bindable radioactive fraction of immunologically active hCG was consistent over time.
Takeaway
The researchers used a special marker to see how long a hormone stays in the body after it's injected, helping doctors understand how to track certain cancers.
Methodology
The study used three different methods to track the plasma disappearance of radioactivity and hCG over 28 days in normal subjects.
Participant Demographics
13 normal subjects, including 8 males and 5 females.
Digital Object Identifier (DOI)
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