Activation and activities of the p53 tumour suppressor protein
2001
Understanding the p53 Tumor Suppressor Protein
publication
Author Information
Author(s): Bálint É, Vousden K H
Primary Institution: NCI at Frederick
Hypothesis
How does the p53 tumor suppressor protein regulate cancer progression?
Conclusion
The p53 protein plays a crucial role in preventing cancer by managing cell cycle arrest and apoptosis in response to stress.
Supporting Evidence
- The p53 protein inhibits malignant progression.
- MDM2 protein regulates p53 function.
- Mutations in p53 are common in cancers.
Takeaway
The p53 protein helps stop cancer by telling cells to stop growing or to die when they are damaged.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website